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WHO Classification of Tumours
Angiomyoma
Connective, subcutaneous and other soft tissues


Definition

Angiomyoma is a benign, slow-growing smooth muscle neoplasm arising in the subcutis or deep dermis of extremities, head and trunk. Angiomyomas are solitary, small (usually <2cm), spherical, sharply demarcated nodules and consist of a large number of vascular channels surrounded by mature and well differentiated smooth muscle cells. Based on the dominant histological pattern, three subtypes of angiomyoma are distinguished:
- The solid type is characterized by compacted, intersecting smooth muscle bundles and numerous small, slit-like vascular channels. Most solid angiomyomas develop in the lower extremities.
- The venous type is characterized by venous vascular channels with thick muscular walls. The smooth muscle bundles are less compact. Tumours of the venous type affect the head more often than the other subtypes.
- The cavernous type is characterized by dilated vascular channels with muscular walls that are difficult to distinguish from intervascular smooth muscle bundles. Most cavernous angiomyomas arise within the upper extremities.
Angiomyoma is a relatively common neoplasm that usually develops in adults between the 4th and 6th decades of life. Women are more often affected. Local excision is generally curative, recurrence after excision is exceptional

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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