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WHO Classification of Tumours
Giant cell tumor of soft parts, NOS
Connective, subcutaneous and other soft tissues


Giant cell tumour of soft tissue (GCT-ST) is a painless, well circumscribed tumour arising in superficial soft tissue, principally of upper and lower extremities, less frequently also of trunk and head and neck. The clinical and histological features of GCT-ST ressemble giant cell tumour of bone . Morphologically, the lesions are characterized by a multinodular growth pattern. The nodules are separated by fibroconnective tissue septa containing haemosiderin-laden macrophages. Mineralization at the tumour periphery is frequent. The cellular infiltrate is composed of mononuclear round or oval cells and multinucleated osteoclast-like giant cells, which are embedded in a rich vascular stroma. Tumour sizes range from 0.7 to 10 cm (mean 3 cm).
GCT-ST occurs in all age groups but predominantly arises in the fifth decade of life. Local recurrence is observed after incomplete surgical excision. Metastases are very rare

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002