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WHO Classification of Tumours
Benign fibrous histiocytoma
Connective, subcutaneous and other soft tissues


Definition

Benign fibrous histiocytoma (BFH) is a benign neoplasm composed of fibroblastic spindle cells in a whorled storiform pattern. It is characterized by the presence of foam cells, inflammatory cells, hemosiderin deposition and stromal haemorrhage.

Deep benign fibrous histiocytoma develops within subcutaneous or deep soft tissues and in parenchymal organs. Most commonly affected sites are the lower limbs and the head and neck region. The lesions are generally well circumscribed and pseudo-encapsulated.
Deep benign fibrous histiocytoma can develop at any age, but most patients are adults >25 years old. Males are more frequently affected. The tumour may recur locally but does not metastasize

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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