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WHO Classification of Tumours
Low-grade myofibroblastic sarcoma
Connective, subcutaneous and other soft tissues


Definition

Low grade myofibroblastic sarcoma is a malignant atypical neoplasm arising from the deep soft tissues. It is histologically characterized by the presence of spindle-shaped fibroblasts and collagenous stroma formation in a storiform growth pattern; the neoplastic cells show at least focally nuclear atypia. Most lesions are solid masses with ill defined margins and diffusely infiltrative; they may contain numerous thin-walled capillaries. The tumour shows a wide anatomic distribution; preferred locations seem to be the extremities and the head and neck region (particularly tongue and oral cavity).
Low grade myofibroblastic sarcoma predominantly affects adults, with a slight male predominance. Local recurrence is common; metastases develop rarely

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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