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WHO Classification of Tumours
Inflammatory myofibroblastic tumor
Connective, subcutaneous and other soft tissues


Inflammatory myofibroblastic tumour (IMT) is a multinodular intermediate fibrocytic neoplasm that arises from soft tissue or viscera. It is histologically characterized by the presence of spindle-shaped myofibroblasts and a chronic inflammatory infiltrate composed of eosinophils, lymphocytes, and plasma cells. IMT can arise at any location throughout the body, but most commonly affects lung, mesentery, and omentum. The tumours are circumscribed, lobulated solid masses; extrapulmonary tumours range in size between 1 and 17 cm (mean diameter: 6 cm).
IMT predominantly affects children and young adults, with a slight predilection for females. Principal treatment is surgical excision. Approximately 25% of extrapulmonary IMT recur; metastases develop rarely (<5%)

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002