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WHO Classification of Tumours
Desmoid-type fibromatosis
Connective, subcutaneous and other soft tissues


Definition

Desmoid-type fibromatosis is an insidious neoplasm arising from the deep soft tissues. It is histologically characterized by the presence of elongated spindle-shaped fibroblasts, collagenous stroma formation, and an infiltrative growth pattern. The tumours are usually firm, poorly circumscribed, sometimes multifocal masses and range in size from 5 to 10 cm. Extra-abdominal fibromatoses arise most frequently in shoulder, chest wall, back, thigh, and head and neck region. Abdominal lesions develop in musculoaponeurotic structures of the abdominal wall, typically in young, gravid or parous women. Intra-abdominal fibromatoses can be found in pelvis or mesentery
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Desmoid-type fibromatoses occur in patients of all age groups. Between puberty and 40 years of age, there is a predilection for females. Local recurrence is frequent, but the tumour does not metastasize

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



.