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WHO Classification of Tumours
Myofibroblastoma
Connective, subcutaneous and other soft tissues


Definition

Myofibroblastoma is a benign soft tissue neoplasm histologically characterized by the presence of spindle shaped myofibroblast-like cells and mast cells in a collagenous stroma. Myofibroblastomas appear to predilect the putative anatomic "milk-line" between axilla and medial groin; the most commonly affected site is the inguinal/groin area. The tumours generally arise in subcutaneous tissue, they are unencapsulated but well circumscribed and range in size from 2 to 13 cm
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Myofibroblastoma occurs in adults (median 55.5 years) and shows a predilection for males. Local excision appears to be curative (limited follow-up time)

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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