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WHO Classification of Tumours
Malignant fibrous histiocytoma
Connective, subcutaneous and other soft tissues


Definition

Malignant fibrous histiocytoma (MFH) is a pleomorphic sarcoma characterized by the presence of fibrohistiocytic and spindle cells arranged in a storiform pattern.

According to the 2003 WHO Classification

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



, this term is now used as a diagnosis of exclusion for sarcomas composed largely of myofibroblasts or undifferentiated mesenchymal cells and is synonymous with undifferentiated high grade pleomorphic sarcoma.