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WHO Classification of Tumours
Blue nevus, NOS
Skin


Definition

Common blue nevus (BN) is a benign lesion histologically characterized by pigmented dendritic spindle-shaped melanocytes which are usually separated by thickened collagen bundles. The lesions are generally confined to the reticular dermis. Concentration around adnexa without adnexal destruction is typical. The tumour cells may extend into nerves and, less frequently, blood vessel walls. BN most frequently develops on the distal upper limbs, followed by the lower limbs, scalp, face and buttocks. It typically presents as a single blue or blue-black papular lesion <1cm in diameter.
Blue nevus is relatively common. It arises mainly in young adults between the 2nd and 4th decades of life and shows a predilection for females. Most tumours are acquired; familial cases usually present with multiple lesions. Simple excision is usually curative. Local recurrence is very rare and malignant transformation exceptional

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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