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WHO Classification of Tumours
Bowen disease


Bowen disease is a form of squamous cell carcinoma in situ . It is a distinct clinicopathological entity and arises from the skin or the mucocutaneous junction. The tumour most frequently develops on sun-exposed glabrous skin areas, particularly on head, face and neck, and presents as an erythematous, scaly, keratotic patch or plaque; multiple contiguos lesions can be observed frequently. Histologically, Bowen disease is characterized by the presence of hyperkeratosis, parakeratosis, dyskeratosis, and acanthosis. The keratotic squamous cells are atypical and display hyperchromatism and abnormal mitotic figures. The dermoepidermal basement membrane is intact. An inflammatory infiltrate of lymphocytes, macrophages, and plasma cells is typically found in the upper dermis.
Bowen disease affects predominantly white males (sex ratio 5:1) in their 6th-8th decades of life. UV damage and ingestion of inorganic arsenic may play a role in the development of the disease. Complete surgical removal of the lesion may be curative

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005


> Bowenoid papulosis is a clinicopathological entity characterised by the presence on the genitalia of solitary or multiple verruca-like papules or plaques with histology resembling full thickness epidermal dysplasia as seen in Bowen disease. The clinical entity of Queyrat erythroplasia is regarded as Bowen disease of the penis and presents as an asymptomatic, red, circumscribed plaque.