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WHO Classification of Tumours
Adenosquamous carcinoma
Skin


Definition

Adenosquamous carcinoma is a rare aggressive variant of squamous cell carcinoma characterized by the formation of mucin secreting glands. The tumour is composed of invasive tongues and columns of atypical squamous cells, connected with glandular structures with epithelial mucin secretion. It may present as a smooth-surfaced dermal nodule or a large, ulcerated, deeply invasive tumour indistinguishable from squamous cell carcinoma or basal cell carcinoma .
Most reported cases of adenosquamous carcinoma developed in elderly patients, with a male predominance. The most commonly affected site is the head and neck region. The clinical course is usually aggressive. The tumours may recur locally or metastasize. Early detection and superficial location are associated with a better prognosis

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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