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WHO Classification of Tumours
Verrucous carcinoma, NOS


Verrucous squamous cell carcinoma is a well differentiated variant of squamous cell carcinoma histologically characterized by a papillary growth pattern, acanthosis, mild cytologic atypia, and pushing tumour margins. An important diagnostic clue is the presence of neutrophils, which may form small abscesses within the epidermis.
The lesions usually penetrate deeply below the level of the surrounding epidermis / mucosa. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot.
Verrucous squamous cell carcinoma occurs predominantly in adult men. The prognosis after complete excision is excellent; after inadequate excision, the recurrence rate is high and the survival decreases

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005