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WHO Classification of Tumours
Acantholytic squamous cell carcinoma,
Skin


Definition

Acantholytic squamous cell carcinoma (ASCC) is a variant of squamous cell carcinoma (SCC) characterized by a loosening of the intercellular bridges, resulting in acantholysis. These tumours may present as intraepidermal (in-situ) or invasive SCC
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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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ASCC develops on sun-exposed skin, predominantly in the head and neck region, in particular on and around the ears. The lesions present as slowly growing scaly and occasionally ulcerated papules or plaques. Areas of acantholysis may produce large intra-epidermal cavities which may extend to adjacent follicular structures.
Adenoid squamous cell carcinoma usually affects elderly individuals with a male predominance. The most important etiologic risk factor is UV-B radiation. The clinical course of ASCC is dependent on the size and depth of the lesion

Click for details
LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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