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WHO Classification of Tumours
Blastic plasmacytoid dendritic cell neoplasm
Skin


Definition

Blastic plasmacytoid dendritic cell (BPDC) neoplasm is a clinically aggressive tumour derived from the precursors of plasmacytoid dendritic cells with a high frequency of cutaneous and bone marrow (BM) involvement and leukaemic dissemination
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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This disease, previously named “CD4+CD56+ hematodermic neoplasm” in the WHO/EORTC Classification of Cutaneous Lymphomas (2005)

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Willemze R, Jaffe ES, Burg G, Cerroni L, Berti E, Swerdlow SH, Ralfkiaer E, Chimenti S, Diaz-Perez JL, Duncan LM, Grange F, Harris NL, Kempf W, Kerl H, Kurrer M, Knobler R, Pimpinelli N, Sander C, Santucci M, Sterry W, Vermeer MH, Wechsler J, Whittaker S, Meijer CJ (2005)
WHO-EORTC classification for cutaneous lymphomas.
Blood 105: 3768-85



and “Blastic NK cell lymphoma” in the third edition of the WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues (2001)
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Jaffe ES, Harris NL, Stein H, Vardiman JW (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues.
3rd Edition
IARC Press: Lyon 2001



, is now named “Blastic plasmacytoid dendritic cell neoplasm” in the fourth edition of the WHO classification of Tumours of Haematopoietic and Lymphoid Tissues (2008)
Click for details
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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