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WHO Classification of Tumours
Angioimmunoblastic T-cell lymphoma
Skin


Definition

Angioimmunoblastic T-cell lymphoma (AITL) is a peripheral T-cell lymphoma characterized by systemic disease and a polymorphous infiltrate with a prominent proliferation of high endothelial venules and follicular dendritic cells. There is a nearly constant association with Epstein Barr virus (EBV), but the neoplastic T cells are EBV negative
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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AITL accounts for approximately for 15−20% of peripheral T-cell lymphomas. It occurs in the middle aged and elderly and the clinical course is usually aggressive.