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WHO Classification of Tumours
Primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma
Skin


Definition

Primary cutaneous CD8 positive aggressive epidermotropic cytotoxic T-cell lymphoma CTCL) is characterized by proliferation of epidermotropic CD8-positive cytotoxic T-cells and aggressive clinical behaviour
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008




Click to access Pubmed
Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, Willemze R (1999)
Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior.
Am J Pathol 155: 483-92



.
This lymphoma accounts for less than 1% of all CTCL and occurs mainly in adults. Most patients present with localized or disseminated eruptive papules, nodules and tumours with central ulceration and necrosis. Dissemination to other sites may occur, incl. lung, testis, central nervous system and oral mucosa

Click for details
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008




Click to access Pubmed
Berti E, Tomasini D, Vermeer MH, Meijer CJ, Alessi E, Willemze R (1999)
Primary cutaneous CD8-positive epidermotropic cytotoxic T cell lymphomas. A distinct clinicopathological entity with an aggressive clinical behavior.
Am J Pathol 155: 483-92



.