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WHO Classification of Tumours
Pleomorphic adenoma
Skin


Definition

Cutaneous mixed tumours (pleomorphic adenomas) are benign adnexal neoplasms. They typically present as solitary, slow-growing dermal/subcutaneous nodules, most frequently on the head and neck. The lesions are well-circumscribed and range in diameter from 1 to 3 cm (in some cases up to 6cm). The growth pattern is biphasic; epithelial cells, often arranged in tubules, solid cords, or islands are surrounded by myoepithelial cells and mesenchymal components. The stroma may be myxoid, chondroid, fibrous, or osteoid, and typically constitutes at least half of the tumour.
Cutaneous mixed tumours affect adults and show a predilection for males. Contrary to the histologically identical mixed tumours of the salivary gland, cutaneous mixed tumours have no tendency for local recurrence; simple excision is curative

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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