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WHO Classification of Tumours
Papillary hidradenoma


Hidradenoma papilliferum is a benign neoplasm arising from the sweat glands. Most frequently affected is the skin of vulva and perianal regions; rare cases of extragenital or ectopic hidradenoma have been observed. The lesion presents as a slow-growing, skin-coloured, cystic dermal nodule that may ulcerate and bleed. The nodule is composed of tubules and papillary structures arranged in a frond-like pattern. The papillae consist of a central axis of connective tissue covered by two layers of epithelial cells. The fibrous stroma surrounding the cystic cavity may contain neutrophils and is separated from the neighbouring dermis by clefts.
Hidradenoma papilliferum affects adults (age range 20-90 years) and shows a clear predilection for women. Complete excision is curative; malignant transformation is very rare

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005