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WHO Classification of Tumours
Papillary syringadenoma


Syringoadenoma (syringocystadenoma papilliferum) is a benign adnexal neoplasm characterized by endophytic invaginations of epithelium into the dermis. Cystic spaces within the dermis contain villous projections. Luminal cells frequently display decapitation secretion. The stroma contains numerous plasma cells. Most syringoadenomas arise in the head and neck area and typically present as one or more warty papules or as a solitary grey or red plaque.
Syringoadenoma is a tumour of childhood and adolescence. At least one third of cases arise in association with an organoid nevus such as nevus sebaceous. Complete excision is curative

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005