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WHO Classification of Tumours
Eccrine dermal cylindroma
Skin


Definition

Cylindroma is a benign adnexal neoplasm characterized by nests of undifferentiated basaloid cells arranged in a mosaic pattern within larger tumour nodules. The cell nests are often surrounded by a rim of densely eosinophilic basement membrane material. The lesions typically present as smooth, circumscribed, domeshaped red-brown papules and nodules, mostly in the dermis, sometimes also in subcutaneous tissue. Most cylindromas arise on the scalp (in particular near the ear) or face. Trunk or proximal extremities may also be affected occasionally. Extensive scalp involvement may create an appearance resembling a headpiece (“turban tumour”).
Cylindroma shows significant overlap with spiradenoma . Hybrid lesions with areas of cylindroma and spiradenoma in juxtaposition may occur; these hybrids are referred to as cylindrospiradenoma or spiradenocylindroma.
Cylindroma is usually cured by simple excision; malignant transformation is extremely rare

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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