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WHO Classification of Tumours
Tubular adenocarcinoma
Skin


Definition

Tubular carcinoma is the malignant counterpart of tubular adenoma , characterized by apocrine differentiation with prominent tubular and ductal structures. It arises in sites rich in apocrine glands, most frequently in the axilla. The tumour typically presents as a firm erythematous nodule, which may be ulcerated. It often involves the whole dermis and may extend into the subcutaneous tissue. Histologically, the tumour is asymmetric, poorly circumscribed and infiltrative and frequently contains areas of necrosis en masse. The stroma ist sparse. A frequent observation is decapitation secretion in the epithelial cells lining the tubules.
Tubular carcinoma arises most frequently in middle-aged patients and shows a slight predilection for women. The tumour is highly malignant and associated with a high rate of metastasis and death

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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