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WHO Classification of Tumours
B-cell prolymphocytic leukaemia
Tumours of haematopoietic and lymphoid tissues


Definition

B-cell prolymphocytic leukaemia (B-PLL) is a neoplasm of B prolymphocytes affecting the peripheral blood (PB), bone marrow (BM) and spleen. Prolymphocytes must exceed 55% of lymphoid cells in the PB. Cases of transformed chronic lymphocytic leukaemia (CLL), CLL with increased prolymphocytes and lymphoid proliferations with relatively similar morpho­logy but carrying the t(11;14)(q13;q32) translocation are excluded.

> Related Topics
Introduction: Classification of lymphoid neoplasms