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WHO Classification of Tumours
Acute erythroid leukaemia
Tumours of haematopoietic and lymphoid tissues


Definition

Acute erythroid leukaemias are acute leukaemias that are characterized by a predominant erythroid population. Two subtypes are recognized based on the presence or absence of a significant myeloid (granulocytic) component:

Erythroleukaemia (erythroid/myeloid)
This subtype of acute erythroid leukaemia is defined by the presence in the BM of ≥50% erythroid precursors in the entire nucleated cell population and ≥20% myeloblasts in the non-erythroid cell population, i.e. the myeloblasts are calculated as a percent of the non-erythroid cells.

Pure erythroid leukaemia
This subtype of acute erythroid leukaemia represents a neoplastic proliferation of immature cells (undifferentiated or proerythroblastic in appearance) committed exclusively to the erythroid lineage (≥80% of BM cells) with no evidence of a significant myeloblastic component

Click to access Pubmed
Garand R, Duchayne E, Blanchard D, Robillard N, Kuhlein E, Fenneteau O, Salomon-Nguyen F, Grange MJ, Rousselot P, Demur C (1995)
Minimally differentiated erythroleukaemia (AML M6 'variant'): a rare subset of AML distinct from AML M6. Groupe Français d'Hématologie Cellulaire.
Br J Haematol 90: 868-75



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