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WHO Classification of Tumours
Acute myelomonocytic leukaemia
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myelomonocytic leukaemia is an acute leukaemia characterized by the proliferation of both neutrophil and monocyte precursors. The PB or BM has ≥20% blasts (including promonocytes); neutro­phils and their precursors and monocytes and their precursors each comprise at least 20% of BM cells. This arbitrary minimal limit of 20% monocytes and their precursors distinguishes acute myelo­monocytic leukaemia from cases of AML with or without maturation in which some monocytes may be present. A high number (usually ≥5x109/L) of monocytic cells may be present in the PB.

> Related Topics
Introduction: AML, not otherwise specified (AML, NOS)
Introduction: Myeloid Neoplasms