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WHO Classification of Tumours
Acute myeloid leukaemia with minimal differentiation
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myeloid leukaemia with minimal ­differentiation is an AML with no evidence of myeloid differentiation by morphology and light microscopy cytochemistry. The myeloid nature of the blasts is demonstrated by immunological markers and/or ultrastructural studies including ultrastructural cytochemistry. Immunophenotyping studies are essential in all cases to distinguish this disease from acute lymphoblastic leukaemia (ALL).

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