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WHO Classification of Tumours
Therapy-related myeloid neoplasms
Tumours of haematopoietic and lymphoid tissues


Definition

This category includes therapy-related acute myeloid leukaemia (t-AML), myelo­dysplastic syndrome (t-MDS) and myelo­dysplastic/myeloproliferative neoplasms (t-MDS/MPN) occurring as late complications of cytotoxic chemotherapy and/or radiation therapy administered for a prior neoplastic or non-neoplastic disorder. Although some patients may be ­diagnosed morphologically as t-MDS, t-MDS/MPN or t-AML according to the number of blasts present, all of these ­therapy-related neoplasms are best considered together as a unique clinical syndrome. Excluded from this category is transformation of MPN since it is often not possible to determine if this is disease evolution or therapy-­related.

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Overview: Myelodysplastic syndromes/neoplasms
Overview: AML with balanced translocations/inversions
Overview: AML with gene mutations
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1

Acute myeloid leukaemia (AML) with myelodysplasia-related changes