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WHO Classification of Tumours
Acute myeloid leukaemia (AML) with myelodysplasia-related changes
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myeloid leukaemia (AML) with myelodysplasia-related changes is an acute leukaemia with 20% or more peri­pheral blood (PB) or bone marrow (BM) blasts with morphological features of myelodysplasia or a prior history of a myelodysplastic syndrome (MDS) or myelodysplastic/myeloproliferative neoplasm (MDS/MPN), or MDS-related cytogenetic abnormalities, and absence of the specific genetic abnormalities of AML with recurrent genetic abnormalities. Patients should not have a history of prior cytotoxic or radiation therapy for an unrelated disease. Therefore, there are three possible reasons for assigning cases to this subtype: AML arising from previous MDS or MDS/MPN; AML with an MDS-­related cytogenetic abnormality; and AML with multilineage dysplasia. A given case may be assigned to this subtype for one, two or all three reasons (Table 6.02).

> Related Topics
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Introduction: Myeloid Neoplasms