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WHO Classification of Tumours
Acute myeloid leukaemia with inv(16)(p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11
Tumours of haematopoietic and lymphoid tissues


Definition

Acute myeloid leukaemia with inv(16) (p13.1q22) or t(16;16)(p13.1;q22); CBFB-MYH11 is an AML that usually shows monocytic and granulocytic differentiation and characteristically abnormal eosinophil component in the BM
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Le Beau MM (2001)
Role of cytogenetics in the diagnosis and classification of hematopoietic neoplasms.
In: Neoplastic Hematopathology, 2nd Edition. Knowles D eds. Lippincott Williams and Wilkins: Philadelphia: pp 319418.




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Marlton P, Keating M, Kantarjian H, Pierce S, O'Brien S, Freireich EJ, Estey E (1995)
Cytogenetic and clinical correlates in AML patients with abnormalities of chromosome 16.
Leukemia 9: 965-71




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Speck NA, Gilliland DG (2002)
Core-binding factors in haematopoiesis and leukaemia.
Nat Rev Cancer 2: 502-13



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