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WHO Classification of Tumours
Refractory anaemia with excess blasts
Tumours of haematopoietic and lymphoid tissues


Definition

Refractory anaemia with excess blasts (RAEB) is a myelodysplastic syndrome (MDS) with 5−19% myeloblasts in the bone marrow (BM) or 2−19% blasts in the peripheral blood (PB). Because of differences in survival and incidence of evolution to acute myeloid leukaemia (AML), two categories of RAEB are recognized: RAEB-1, defined by 5−9% blasts in the BM or 2−4% blasts in the PB, and RAEB-2, defined by 10−19% blasts in the BM or 5−19% blasts in the PB
Click to access Pubmed
Greenberg P, Cox C, LeBeau MM, Fenaux P, Morel P, Sanz G, Sanz M, Vallespi T, Hamblin T, Oscier D, Ohyashiki K, Toyama K, Aul C, Mufti G, Bennett J (1997)
International scoring system for evaluating prognosis in myelodysplastic syndromes.
Blood 89: 2079-88



. The presence of Auer rods in blasts qualifies a case as RAEB-2 irrespective of the blast percentage
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Germing U, Strupp C, Kuendgen A, Aivado M, Giagounidis A, Hildebrandt B, Aul C, Haas R, Gattermann N (2006)
Refractory anaemia with excess of blasts (RAEB): analysis of reclassification according to the WHO proposals.
Br J Haematol 132: 162-7



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> Related Topics
Overview: Myelodysplastic syndromes/neoplasms
Acute myeloid leukaemia (AML) with myelodysplasia-related changes
Therapy-related myeloid neoplasms
Introduction: Myeloid Neoplasms