Juvenile myelomonocytic leukaemia
Tumours of haematopoietic and lymphoid tissues
Juvenile myelomonocytic leukaemia (JMML) is a clonal haematopoietic disorder of childhood characterized by proliferation principally of the granulocytic and monocytic lineages. Blasts plus promonocytes account for <20% of cells in peripheral blood (PB) and bone marrow (BM). Erythroid and megakaryocytic abnormalities are frequently present
Amenomori T, Tomonaga M, Yoshida Y, Kuriyama K, Matsuo T, Jinnai I, Ichimaru M, Omiya A, Tsuji Y (1986)
Cytogenetic evidence for partially committed myeloid progenitor cell origin of chronic myelomonocytic leukaemia and juvenile chronic myeloid leukaemia: both granulocyte-macrophage precursors and erythroid precursors carry identical marker chromosome.
Br J Haematol 64: 539-46
Busque L, Gilliland DG, Prchal JT, Sieff CA, Weinstein HJ, Sokol JM, Belickova M, Wayne AS, Zuckerman KS, Sokol L (1995)
Clonality in juvenile chronic myelogenous leukemia.
Blood 85: 21-30
Miles DK, Freedman MH, Stephens K, Pallavicini M, Sievers EL, Weaver M, Grunberger T, Thompson P, Shannon KM (1996)
. BCR-ABL1 is absent, whereas mutations involving genes of the RAS/MAPK pathway are characteristic.
Patterns of hematopoietic lineage involvement in children with neurofibromatosis type 1 and malignant myeloid disorders.
Blood 88: 4314-20
> Related Topics
Chronic myelogenous leukaemia, BCR-ABL1 positive
Chronic myelomonocytic leukaemia
Acute myelomonocytic leukaemia
Overview: Myelodysplastic syndromes/neoplasms
Introduction: Myeloid Neoplasms
|Diagnostic criteria of juvenile myelomonocytic leukaemia|