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WHO Classification of Tumours
Atypical chronic myeloid leukaemia, BCR-ABL1 negative
Tumours of haematopoietic and lymphoid tissues


Definition

/span>typical chronic myeloid leukaemia, BCR-ABL1 negative (aCML) is a leukaemic disorder with myelodysplastic as well as myeloproliferative features at the time of initial diagnosis. It is characterized by principal involvement of the neutrophil lineage with leukocytosis resulting from an increase of morphologically dysplastic neutrophils and their precursors. However, multilineage dysplasia is common and reflects the stem cell origin of aCML. The neoplastic cells do not have a BCR-ABL1 fusion gene.

> Related topics=
Chronic myelomonocytic leukaemia
Chronic myelogenous leukaemia, BCR-ABL1 positive
Overview: Myelodysplastic syndromes/neoplasms
Myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB or FGFR1
Introduction: Myeloid Neoplasms




Diagnostic criteria for atypical chronic meyeloid leukaemia, BCR-ABL negative
Diagnostic criteria for atypical chronic meyeloid leukaemia, BCR-ABL negative