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WHO Classification of Tumours
Chronic neutrophilic leukaemia
Tumours of haematopoietic and lymphoid tissues


Definition

Chronic neutrophilic leukaemia (CNL) is a rare myeloproliferative neoplasm, characterized by sustained peripheral blood (PB) neutrophilia, bone marrow (BM) hypercellularity due to neutrophilic granulocyte proliferation, and hepatosplenomegaly. There is no Philadelphia (Ph) chromosome or BCR-ABL1 fusion gene. The diagnosis requires exclusion of reactive neutrophilia and other myeloproliferative neoplasms.

> Related Topics
Chronic myelogenous leukaemia, BCR-ABL1 positive
Atypical chronic myeloid leukaemia, BCR-ABL1 negative
Chronic myelomonocytic leukaemia
Introduction: Myeloid Neoplasms






Diagnostic criteria for chronic neutrophilic leukaemia
Diagnostic criteria for chronic neutrophilic leukaemia