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WHO Classification of Tumours
Chronic myelogenous leukaemia, BCR-ABL1 positive
Tumours of haematopoietic and lymphoid tissues


Definition

Chronic myelogenous leukaemia (CML) is a myeloproliferative neoplasm that originates in an abnormal pluripotent bone marrow (BM) stem cell and is consistently associated with the BCR-ABL1 fusion gene located in the Philadelphia (Ph) chromosome
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Bartram CR, de Klein A, Hagemeijer A, van Agthoven T, Geurts van Kessel A, Bootsma D, Grosveld G, Ferguson-Smith MA, Davies T, Stone M (1983)
Translocation of c-ab1 oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia.
Nature 306: 277-80




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Melo JV, Barnes DJ (2007)
Chronic myeloid leukaemia as a model of disease evolution in human cancer.
Nat Rev Cancer 7: 441-53




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Nowell PC , Hungerford DA (1960)
A minutre chromosome in human chronic granulocytic leukemia.
Science 132: 14971500.




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Rowley JD (1973)
Letter: A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining.
Nature 243: 290-3



. Although the initial major finding is neutrophilic leukocytosis, the BCR-ABL1 is found in all myeloid lineages as well as in some lymphoid cells and endothelial cells. The natural history of untreated CML is bi- or triphasic: an initial indolent chronic phase (CP) is followed by an accelerated phase (AP), a blast phase (BP) or both.

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Atypical chronic myeloid leukaemia, BCR-ABL1 negative
Chronic neutrophilic leukaemia
Chronic myelomonocytic leukaemia
B lymphoblastic leukaemia/lymphoma with t(9;22)(q34;q11.2);BCR-ABL1
Mixed phenotype acute leukaemia with t(9;22)(q34;q11.2);BCR-ABL1
Introduction: Myeloid Neoplasms