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WHO Classification of Tumours
Splenic marginal zone lymphoma
Tumours of haematopoietic and lymphoid tissues


Splenic marginal zone lymphoma (SMZL) is a B-cell neoplasm composed of small lymphocytes which surround and replace the splenic white pulp germinal centres, efface the follicle mantle and merge with a peripheral (marginal) zone of larger cells including scattered transformed blasts; both small and larger cells infiltrate the red pulp. Splenic hilar lymph nodes and bone marrow (BM) are often involved; lymphoma cells may be found in the peripheral blood (PB) as villous lymphocytes.

> Related Topics
Splenic B-cell lymphoma/leukaemia, unclassifiable
Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma)
Nodal marginal zone lymphoma
Introduction: Classification of lymphoid neoplasms