Plasma cell myeloma is a BM-based, multifocal plasma cell neoplasm associated with an M-protein in serum and/or urine. In most cases there is disseminated BM involvement. The disease spans a clinical spectrum from asymptomatic to aggressive forms and disorders due to deposition of abnormal immunoglobulin chains in tissues
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Malpas J, Bergsagel D, Kyle R, Anderson K (Eds.) Myeloma: Biology and Management 3rd Edition Saumders: Philadelphia 2004
. The diagnosis is based on a combination of pathological, radiological and clinical features (Table 10.05).