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WHO Classification of Tumours
Intraosseous well differentiated osteosarcoma
Bone


Definition

Intraosseous well differentiated osteosarcoma is a low grade osteosarcoma arising from the medullary cavity of bone. The tumour predominantly affects the long bones, with a distinct predilection for the distal femur and proximal tibia. The majority of low grade central osteosarcomas are poorly marginated and show some degree of cortical disruption with or without soft tissue extension. The tumours are composed of a fibroblastic stroma with variable amounts of osteoid production and typically contain areas of heavy mineralisation.
Low grade central osteosarcoma is rare. Peak incidence is in the second and third decades of life; males and females are equally affected. The prognosis is more favorable than that for conventional osteosarcoma. Nevertheless, local recurrencies after inadequate resections are frequent

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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