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WHO Classification of Tumours
Small cell osteosarcoma


Small cell osteosarcoma is a variant of osteosarcoma , composed of small cells with variable degrees of osteoid production. Most tumours arise from the metaphysis of long bones. They contain a lytic component, with aggressive destruction of the cortex, and typically mineralized tissue.
Small cell osteosarcoma occurs in all age groups with a peak incidence in the second decade of life. There is a slight predilection for females (ratio 1.1 to 1). The prognosis is usually unfavorable and somewhat worse than that for conventional osteosarcoma

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002