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WHO Classification of Tumours
Clear cell chondrosarcoma
Bone


Definition

Clear cell chondrosarcoma is a rare, usually low grade malignant variant of chondrosarcoma , which predilects the epiphyseal ends of long bones. The tumour forms well defined lesions ranging from 2 to 13 cm in diameter and is histologically characterized by bland clear cells in addition to hyaline cartilage.
Men are almost three times more frequently affected. Most patients are between 25 and 50 years of age. En bloc excision with clear margins is usually curative. Marginal excision or curettage has been reported to result in an 86% recurrence rate. In such incompletely excised cases, metastases, usually to the lungs and other skeletal sites, may develop, with an overall mortality rate of approximately 15%

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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