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WHO Classification of Tumours
Mesenchymal chondrosarcoma
Bone


Definition

Mesenchymal chondrosarcoma is a rare malignant variant of chondrosarcoma and most commonly affects the craniofacial bones (especially the jawbones), the ribs, the ilium, and the vertebrae. The tumours are usually well defined, circumscribed masses varying from 3 to 30 cm in diameter. They are primarily lytic and destructive with poor margins, not significantly differing from ordinary chondrosarcoma in most cases. Expansion of the bone is frequent, and cortical destruction or cortical breakthrough with extraosseous extension of soft tissue is common.
Mesenchymal chondrosarcoma is histologically composed of highly undifferentiated small round cells and islands of well differentiated hyaline cartilage

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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The tumour occurs at any age, with a peak incidence in the second and the third decades. It is highly malignant, with a strong tendency toward local recurrence and distant metastasis which are observed even after a delay of more than 20 years. The clinical course is frequently protracted and relentless, making longterm follow up mandatory

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



.