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WHO Classification of Tumours
Chondromyxoid fibroma
Bone


Definition

Chondromyxoid fibroma is an uncommon, benign neoplasm arising from the bone. It is histologically characterized by lobules of spindle-shaped or stellate chondrocytes and abundant myxoid or chondroid stroma formation. Multinucleated giant cells are frequently found. The tumour is well demarcated from the surrounding bone. It can occur in almost any osseous site, but most frequently affects the long bones, in particular the proximal tibia and the distal femur. Most lesions are entirely lucent. There may be cortical destruction and extension into soft tissues, but the adjacent periosteum is typically intact.
Chondromyxoid fibroma is one of the least common tumours of bone. It presents mostly in the second and third decades of life and more often in males than in females. The prognosis is excellent, even in the case of recurrence

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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