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WHO Classification of Tumours
Chondroblastoma, NOS
Bone


Definition

Chondroblastoma is a benign, lytic neoplasm usually arising from the cartilage in epiphysis and metaphysis of immature bone. In more than 75% of cases, the long bones are affected; the most common sites are distal and proximal femur, proximal tibia, and proximal humerus. The tumours are relatively small (3 to 6 cm), sharply demarcated, and may have a thin sclerotic border. The presence of a sclerotic rim, along with the younger age of the patients, helps to differentiate chondroblastoma from giant cell tumor of bone , which generally lacks a sclerotic border and occurs in patients older than 20 years.
The characteristic cells are uniform, round to polygonal chondroblasts. Other typical features are osteoclast-like giant cells, myxoid stroma formation, calcification, and mitotic activity

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Chondroblastoma occurs most frequently in children and young adults (10-25 years of age), with a higher incidence in males. More than 80% of chondroblastomas are successfully treated by simple curettage with bone grafting. Local recurrence rates are 14-18% and occur usually within two years

Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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