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WHO Classification of Tumours
Chondrosarcoma, NOS


Chondrosarcoma (CHS) is a malignant mesenchymal tumor arising from cartilage-forming tissues, histologically characterized by a lobular growth pattern and with abundant matrix production. Myxoid changes or chondroid matrix liquefaction are common features, calcification or ossification may also be present.

> Primary chondrosarcoma
Primary CHS arises de novo in a previously healthy bone. The most commonly affected sites are pelvic bones, femur, humerus and ribs. In the metaphysis or diaphysis of the long bones, primary CHS produces fusiform expansion with cortical thickening of the bone. Cortical erosion or destruction is typical.
Primary CHS is the third most common primary malignancy of bone after myeloma and osteosarcoma . It affects middle-aged to elderly adults, with a peak incidence in the fifth to seventh decades of life, with a slight preference for males. Histological parameters associated with increased risk of recurrence and metastasis include grade, tumour necrosis, mitotic count and myxoid tumour matrix

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002


> Secondary chondrosarcoma
Secondary CHS develops in a preexisting benign cartilaginous lesion, usually osteochondroma , enchondroma or enchondromatosis .