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WHO Classification of Tumours
Primary mediastinal (thymic) large B-cell lymphoma
Thymus


Definition

Primary mediastinal large B-cell lymphoma (PMBL) is a non-Hodgkin lymphoma of the mediastinum, probably arising in the thymus. Invasion of lungs, pleura or pericardium is frequent as is metastatic spread in the course of disease progression. PMBL is histologically characterized by a massive diffuse lymphocytic proliferation associated with compartmentalizing fibrosis.
PMBL accounts to 2-4% of non-Hodgkin lymphomas and manisfests preferentially in young adults, with a marked female predominance

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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



. Response to intensive chemotherapy, with or without radiotherapy, is usually good and clinical outcome of PMBL patients is considered equivalent or superior to that of other patients with diffuse large B-cell lymphoma (DLBCL)
Click for details
Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008



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