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WHO Classification of Tumours
Langerhans cell histiocytosis
Bronchus and lung


Langerhans cell histiocytosis (LCH) is a rare clonal neoplastic proliferation of Langerhans-type cells that express CD1a, langerin and S100 protein, and shows Birbeck granules by ultrastructural examination
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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008


Langerhans cell histiocytosis of the lung is almost always a disease of smokers, usually non-clonal and thought to represent a reactive process.