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WHO Classification of Tumours
Bronchioloalveolar carcinoma, NOS
Bronchus and lung


Definition

Bronchiolo-alveolar adenocarcinoma carcinoma (BAC) is histologically characterized by cuboidal to columnar shaped cells that grow along alveolar walls in a lepidic fashion.

Two variants are distinguished

Click for details
Travis WD, Brambilla E, Müller-Hermelink HK, Harris CC (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Lung, Pleura, Thymus and Heart.
3rd Edition
IARC Press: Lyon 2004



:

> Non-mucinous variant of BAC
This lesion typically shows Clara cell and/or type II cell differentiation.

> Mucinous BAC
This variant is low grade and composed of tall columnar cells with basal nuclei and pale cytoplasm, sometimes resembling goblet cells, with varying amounts of cytoplasmic mucin and mucus accumulation in the surrounding alveolar spaces. Cytologic atypia is is typically minimal.