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WHO Classification of Tumours
Adenosquamous carcinoma
Pancreas


Definition

A carcinoma composed of malignant glandular cells and malignant squamous cells.

Adenosquamous carcinoma of the pancreas
Adenosquamous carcinoma is a malignant epithelial neoplasm of the pancreas that has both significant ductal and significant squamous differentiation. The squamous component should account for at least 30% of the neoplasm. Neoplasms with these features were previously designated adenoacanthoma, mixed squamous and adenocarcinoma, and mucoepidermoid carcinoma. Adenosquamous carcinomas account for only 14% of exocrine pancreatic malignancies

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Hsu JT, Yeh CN, Chen YR, Chen HM, Hwang TL, Jan YY, Chen MF (2005)
Adenosquamous carcinoma of the pancreas.
Digestion 72: 104-8




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Madura JA, Jarman BT, Doherty MG, Yum MN, Howard TJ (1999)
Adenosquamous carcinoma of the pancreas.
Arch Surg 134: 599-603



. Pure squamous carcinoma of the pancreas is very rare, and a metastasis from another site (e.g. lung) should be excluded if a neoplasm has purely squamous differentiation. Even focal glandular differentiation in a carcinoma with predominant squamous differentiation warrants a diagnosis of adenosquamous carcinoma. Patients with resected adenosquamous carcinoma have a poorer prognosis (median survival, 711 months) than do those with pure adenocarcinoma
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Kardon DE, Thompson LD, Przygodzki RM, Heffess CS (2001)
Adenosquamous carcinoma of the pancreas: a clinicopathologic series of 25 cases.
Mod Pathol 14: 443-51




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Okabayashi T, Hanazaki K (2008)
Surgical outcome of adenosquamous carcinoma of the pancreas.
World J Gastroenterol 14: 6765-70




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Voong KR, Davison J, Pawlik TM, Uy MO, Hsu CC, Winter J, Hruban RH, Laheru D, Rudra S, Swartz MJ, Nathan H, Edil BH, Schulick R, Cameron JL, Wolfgang CL, Herman JM (2010)
Resected pancreatic adenosquamous carcinoma: clinicopathologic review and evaluation of adjuvant chemotherapy and radiation in 38 patients.
Hum Pathol 41: 113-22




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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