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WHO Classification of Tumours
Signet ring cell carcinoma


A usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus.

Signet-ring cell carcinoma of the pancreas
This is an extremely rare tumour. It is an adenocarcinoma composed almost exclusively of poorly cohesive neoplastic epithelial cells containing intracytoplasmic mucin that displaces the nuclei towards the periphery, infiltrating in an individual cell pattern

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Fagih M, Serra S, Chetty R (2007)
Paucicellular infiltrating ductal carcinoma of pancreas: an unusual variant.
Ann Diagn Pathol 11: 46-8

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Tracey KJ, O'Brien MJ, Williams LF, Klibaner M, George PK, Saravis CA, Zamcheck N (1984)
Signet ring carcinoma of the pancreas, a rare variant with very high CEA values. Immunohistologic comparison with adenocarcinoma.
Dig Dis Sci 29: 573-6

. A variable amount of extracellular mucin is usually present. The prognosis is extremely poor. A gastric or breast primary should always be excluded before making this diagnosis
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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010