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Glucagonoma, malignant
Pancreas Definition Glucagonoma is a glucagon-producing endocrine neoplasm arising from the alpha cells of the pancreas. It often displays vascular invasion and may metastasize to other anatomic sites 
World Health Organization Classification of Tumours. Pathology and Genetics of Tumors of Endocrine Organs IARC Press: Lyon 2004 It may be clinically associated with necrolytic erythema migrans, diarrhea, diabetes, glossitis, weight loss, malabsorption, and anemia. Almost 25% of patients experience thromboembolic complications, and 50% have liver metastases at the time of diagnosis. Glucagonomas are occasionally part of MEN1 
A familial glucagonoma syndrome: genetic, clinical and biochemical features. Am J Med 70: 1017-26 Commentary: Neuroendocrine tumours of the digestive system |