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WHO Classification of Tumours
Leiomyosarcoma, NOS
Gallbladder and extrahepatic biliary tract


Definition

Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma , myxoid leiomyosarcoma , granular cell and inflammatory leiomyosarcoma
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Leiomyosarcoma of the gallbladder and extrahepatic biliary tract
Epstein-Barr virus (EBV)-associated leiomyosarcoma/smooth muscle tumour rarely involves the gallbladder wall

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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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