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WHO Classification of Tumours
Goblet cell carcinoid
Gallbladder and extrahepatic biliary tract


Definition

Goblet cell carcinoid is composed of small, rounded nests of signet ring-like cells resembling normal intestinal goblet cells, except for the nuclear compression. Glandular lumina are infrequently observed. The cells dispay mild-to-moderate atypia, low mitotic activity with a Ki67 proliferation index < 20%
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Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS (2008)
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
Am J Surg Pathol 32: 1429-43



. Lysozyme-positive Paneth cells as well as foci resembling Brunner glands may be present
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Isaacson P (1981)
Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumor).
Am J Surg Pathol 5: 213-24



. Mucin staining is intensely positive within goblet cells and extracellular mucin pools.

Immunohistochemically, the endocrine cell component is positive for chromogranin A, synaptophysin, CD56 (NCAM1), serotonin, enteroglucagon, somatostatin, and/or PP

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Höfler H, Klöppel G, Heitz PU (1984)
Combined production of mucus, amines and peptides by goblet-cell carcinoids of the appendix and ileum.
Pathol Res Pract 178: 555-61




Click to access Pubmed
Isaacson P (1981)
Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumor).
Am J Surg Pathol 5: 213-24




Click to access Pubmed
van Eeden S, Offerhaus GJ, Hart AA, Boerrigter L, Nederlof PM, Porter E, van Velthuysen ML (2007)
Goblet cell carcinoid of the appendix: a specific type of carcinoma.
Histopathology 51: 763-73



. The goblet cells express CEA, keratins 19 and 20 and MUC2
Click to access Pubmed
Tang LH, Shia J, Soslow RA, Dhall D, Wong WD, O'Reilly E, Qin J, Paty P, Weiser MR, Guillem J, Temple L, Sobin LH, Klimstra DS (2008)
Pathologic classification and clinical behavior of the spectrum of goblet cell carcinoid tumors of the appendix.
Am J Surg Pathol 32: 1429-43




Click to access Pubmed
van Eeden S, Offerhaus GJ, Hart AA, Boerrigter L, Nederlof PM, Porter E, van Velthuysen ML (2007)
Goblet cell carcinoid of the appendix: a specific type of carcinoma.
Histopathology 51: 763-73



. Ultrastructurally, densecore endocrine granules and mucin droplets are both found
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Edmonds P, Merino MJ, LiVolsi VA, Duray PH (1984)
Adenocarcinoid (mucinous carcinoid) of the appendix.
Gastroenterology 86: 302-9




Click to access Pubmed
Höfler H, Klöppel G, Heitz PU (1984)
Combined production of mucus, amines and peptides by goblet-cell carcinoids of the appendix and ileum.
Pathol Res Pract 178: 555-61



occasionally within the cytoplasm of the same cell
Click to access Pubmed
Isaacson P (1981)
Crypt cell carcinoma of the appendix (so-called adenocarcinoid tumor).
Am J Surg Pathol 5: 213-24




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Bosman FT, Carneiro F, Hruban RH, Theise ND (Eds.)
WHO Classification of Tumours of the Digestive System.
4th Edition
International Agency for Research on Cancer: Lyon 2010



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Commentary: Preneoplastic lesions of the digestive system